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Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism.
Han L, Huang D, Wu S, Liu S, Wang C, Sheng Y, Lu X, Broxmeyer HE, Wan J, Yang L. Han L, et al. Nat Cell Biol. 2023 Jul;25(7):1033-1046. doi: 10.1038/s41556-023-01162-4. Epub 2023 Jun 1. Nat Cell Biol. 2023. PMID: 37264180 Free PMC article.
LIPTER binds phosphatidic acid and phosphatidylinositol 4-phosphate on LD surface membranes and the MYH10 protein, connecting LDs to the MYH10-ACTIN cytoskeleton and facilitating LD transport. ...Our findings unveil a molecular connector role of LIPTER in intramyocy …
LIPTER binds phosphatidic acid and phosphatidylinositol 4-phosphate on LD surface membranes and the MYH10 protein, connecting LDs to …
Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.
Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR. Kim HT, et al. Nat Commun. 2018 Nov 2;9(1):4600. doi: 10.1038/s41467-018-06833-7. Nat Commun. 2018. PMID: 30389913 Free PMC article.
In a forward genetic screen for modulators of mouse lung development, we identified the non-muscle myosin II heavy chain gene, Myh10. Myh10 mutant pups exhibit cyanosis and respiratory distress, and die shortly after birth from differentiation defects in alveolar ep …
In a forward genetic screen for modulators of mouse lung development, we identified the non-muscle myosin II heavy chain gene, Myh10. …
A point mutation in Myh10 causes major defects in heart development and body wall closure.
Ma X, Adelstein RS. Ma X, et al. Circ Cardiovasc Genet. 2014 Jun;7(3):257-65. doi: 10.1161/CIRCGENETICS.113.000455. Epub 2014 May 13. Circ Cardiovasc Genet. 2014. PMID: 24825879 Free PMC article.
Previous work, using knockout and hypomorphic mice, showed that Myh10 encoding myosin heavy chain II-B is critical for cardiac and brain development. ...
Previous work, using knockout and hypomorphic mice, showed that Myh10 encoding myosin heavy chain II-B is critical for cardiac and br …
Generation of heterozygous (MRli003-A-1) and homozygous (MRli003-A-2) MYH10 knockout human iPSC lines.
Zhang F, Meier AB, Laugwitz KL, Dorn T, Moretti A. Zhang F, et al. Stem Cell Res. 2021 Dec;57:102612. doi: 10.1016/j.scr.2021.102612. Epub 2021 Nov 29. Stem Cell Res. 2021. PMID: 34864222 Free article.
Myosin-10, also known as non-muscle myosin IIB, is a cytoskeletal protein implicated in cardiac development and disease. In humans, it is encoded by the MYH10 gene. Using CRISPR/Cas9 gene editing technology, we generated two MYH10 knockout human iPSC lines - one het …
Myosin-10, also known as non-muscle myosin IIB, is a cytoskeletal protein implicated in cardiac development and disease. In humans, it is en …
Transcription factor defects causing platelet disorders.
Daly ME. Daly ME. Blood Rev. 2017 Jan;31(1):1-10. doi: 10.1016/j.blre.2016.07.002. Epub 2016 Jul 16. Blood Rev. 2017. PMID: 27450272 Free article. Review.
Some of the transcription factor defects are also associated with an increased predisposition to haematologic malignancies (RUNX1, ETV6), abnormal erythropoiesis (GATA-1, GFI1b, ETV6) and immune dysfunction (FLI1). The persistence of MYH10 expression in platelets is a surr …
Some of the transcription factor defects are also associated with an increased predisposition to haematologic malignancies (RUNX1, ETV6), ab …
Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development.
Huang Y, Wang X, Wang X, Xu M, Liu M, Liu D. Huang Y, et al. Gene Expr Patterns. 2013 Oct;13(7):265-70. doi: 10.1016/j.gep.2013.04.005. Epub 2013 May 9. Gene Expr Patterns. 2013. PMID: 23665442
The three NM II isoforms share a very similar molecular structure and play important roles in a variety of fundamental biological processes. NM II-B (myh10) has been shown to be essential for the formation of mouse neural system and heart. ...It was maintained and e …
The three NM II isoforms share a very similar molecular structure and play important roles in a variety of fundamental biological processes. …
Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.
Arrigo AB, Lin JI. Arrigo AB, et al. Int J Mol Sci. 2021 Aug 16;22(16):8816. doi: 10.3390/ijms22168816. Int J Mol Sci. 2021. PMID: 34445520 Free PMC article. Review.
Although there is no impact on CNCCs in Lrp2 mutants, the loss of LRP2 results in the depletion of sonic hedgehog (SHH)-dependent cells in the second heart field. SHH is known to be crucial for CNCC survival and proliferation, which suggests LRP2 has a non-autonomous role …
Although there is no impact on CNCCs in Lrp2 mutants, the loss of LRP2 results in the depletion of sonic hedgehog (SHH)-dependent cells in t …
Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development.
Ridge LA, Mitchell K, Al-Anbaki A, Shaikh Qureshi WM, Stephen LA, Tenin G, Lu Y, Lupu IE, Clowes C, Robertson A, Barnes E, Wright JA, Keavney B, Ehler E, Lovell SC, Kadler KE, Hentges KE. Ridge LA, et al. PLoS Genet. 2017 Oct 30;13(10):e1007068. doi: 10.1371/journal.pgen.1007068. eCollection 2017 Oct. PLoS Genet. 2017. PMID: 29084269 Free PMC article.
The coronary vasculature is an essential vessel network providing the blood supply to the heart. Disruptions in coronary blood flow contribute to cardiac disease, a major cause of premature death worldwide. ...Positional cloning and candidate gene analysis revealed that th …
The coronary vasculature is an essential vessel network providing the blood supply to the heart. Disruptions in coronary blood flow c …
CCND1 Overexpression in Idiopathic Dilated Cardiomyopathy: A Promising Biomarker?
Dehghani K, Stanek A, Bagherabadi A, Atashi F, Beygi M, Hooshmand A, Hamedi P, Farhang M, Bagheri S, Zolghadri S. Dehghani K, et al. Genes (Basel). 2023 Jun 10;14(6):1243. doi: 10.3390/genes14061243. Genes (Basel). 2023. PMID: 37372424 Free PMC article.
Cardiomyopathy, a disorder of electrical or heart muscle function, represents a type of cardiac muscle failure and culminates in severe heart conditions. ...In the following, several genes, including VEGFA, IGF1, APP, STAT1, CCND1, MYH10, and MYH11, were sele …
Cardiomyopathy, a disorder of electrical or heart muscle function, represents a type of cardiac muscle failure and culminates in seve …
Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons.
Recuenco MC, Ohmori T, Tanigawa S, Taguchi A, Fujimura S, Conti MA, Wei Q, Kiyonari H, Abe T, Adelstein RS, Nishinakamura R. Recuenco MC, et al. J Am Soc Nephrol. 2015 May;26(5):1081-91. doi: 10.1681/ASN.2014030281. Epub 2014 Aug 28. J Am Soc Nephrol. 2015. PMID: 25168025 Free PMC article.
Here, we analyzed the roles of Myh9 and Myh10 in the developing kidney. Ureteric bud-specific depletion of Myh9 resulted in no apparent phenotypes, whereas mesenchyme-specific Myh9 deletion caused proximal tubule dilations and renal failure. Mesenchyme-specific Myh9/Myh
Here, we analyzed the roles of Myh9 and Myh10 in the developing kidney. Ureteric bud-specific depletion of Myh9 resulted in no appare …
32 results